novacutis dermal filler manufacturer



Hyaluronic acid dermal filler injectable gels

Liquidimplant® represents a family of dermal fillers (Cutis, SubCutis and Labium), which are indicated for the treatment of facial lipoatrophy.

Liquidimplant® can be administrated to restore facial volume and contouring. Depending on the area of the face affected, they can be used in the midfacial and frontal regions of the face including the infra and supraorbital regions. The peroral area including the lips and chin.

Liquidimplant® is available in the different versions in order to allow for the treatment of facial volume and contour loss of varying degrees and in different facial regions.

Liquidimplant® Cutis

Liquidimplant® Cutis is intended for the treatment of lower-grade volume and contour loss, as typically found in the area of the nasolabial folds, eyebrows and infra- or supraorbital region of the face.

Liquidimplant® SubCutis

Liquidimplant® SubCutis is intended for the treatment of higher-grade volume and/or contour loss and can be used to achieve augmentation and/or contouring of the cheek, jaw and chin region.

Liquidimplant® Labium

Liquidimplant® Cutis is intended for the treatment of lower-grade volume and contour loss, as typically found in the area of the nasolabial folds, eyebrows and infra- or supraorbital region of the face.

Instructions and Indications

Liquidimplant® is an injectable, space-occupying reconstructive material composed of hyaluronic acid gel indicated for treatment of facial lipoatrophy. It can be administered to restore volume loss in facial subcutaneous adipose tissue, and/or correction of contour deficiencies and anatomic deformities.

Key information

Naturally found in the skin of humans and, in fact, all mammals, hyaluronic acid is a polysaccharide chain, which contributes to hydration and elasticity of the skin. Links between different Hyaluronic Acid polymer chains are promoted. On the other hand, less efficient links between portions of the same chain are minimized thanks to the advanced cross-linking process of Liquidimplant. The degree of cross-linking is then selected to provide a desirable level of durability in the skin. Optimizing all these properties provides a dermal filler with superior performance and patient satisfaction. This cross-linked Hyaluronic Acid is finely tuned with the size of the particles to produce a gel able to flow readily through a fine needle and to provide a soft, smooth feel to the augmented skin. The osmolality and pH of the gel are balanced to be compatible with the fluid in the skin, neither drawing-in nor releasing water, minimizing the need for over-correction. A slow expansion of the gel particles partly offsets the natural loss in dermal filler volume as time goes by, maintaining the level of correction.

Because Liquidimplant is a non-animal based Hyaluronic Acid filler gel manufactured by bio fermentation, the risks of allergic reactions are minimal. Liquidimplant exceeds the highest standards of purity for Hyaluronic Acid´s and, as a consequence, it is extremely safe and non-pathogenic for human use. In order to prove the safety and efficacy of the product, these tests were strictly conducted:

  • Biocompatibility
  • Cytotoxicity
  • Sensitization
  • PH
    Intra cutaneous reactivity
  • Osmolality
  • Sterility
  • Residual BDDE
  • Acute and Sub chronic toxicity

Liquidimplant high compatibility with human tissues allows its placement in the dermis with no disturbances of the delicate homeostatic processes of the skin. Because of the presence of naturally occurring hyaluronidases, even this long lasting advanced filler products will eventually break down and will be naturally cleared by the body. When properly injected there is no migration from the implant site.

The long lasting characteristics of any Hyaluronic Acid filler is directly proportional to the concentration and the degree of cross-linking achieved. Once injected, Hyaluronic Acid is gradually degraded by hyaluronidases and cleared by the body. The Liquidimplant cross-linking technology ensures long lasting results while not sacrificing viscosity even though the products remain easy to inject. Overall, this innovative engineering makes the Liquidimplant product line unique and exceptionally durable.

Liquidimplant line of fillers is easy to inject. Our technology enables even the highly viscous Liquidimplant SubCutis to be easily injected with fine gauge needles without compromising the integrity of the gel. The ergonomic design of our syringes provides greater ease of use allowing the physician a much higher degree of comfort when injecting.

Important Safety Considerations for filler injections

Safety Considerations

Patients with serious allergies to drugs, that have previously required in-hospital treatment, should not be injected with fillers. Products should be injected into the skin, under the skin, or in the lips. If there are known problems with the skin, for example sores, pimples, rashes, hives, cysts, or infection, the injections should be postponed until the problems are solved. After treatment, you might have little pain, in some cases bruising or swelling, redness and rarely tenderness. These are typically mild and normally last 3 to 7 days in nasolabial folds, and up to 5 days in the lips. To avoid bruising and bleeding, you should not use the products if you have recently used drugs that thin your blood or prevent clotting. Products should not be used during pregnancy, when breastfeeding, or in patients under 18 years. Our reference doctors advise to limit treatment volume to 2 mg/ml in wrinkles and folds, such as nasolabial folds, and to 2 mg/ml per lip, as greater amounts could increase the possibility of adverse event.